Differential Consequences of Unilateral Nasal Air-Puff Stimulation on Breathing Pattern and Respiratory System Mechanics in Tracheotomized Rats
نویسندگان
چکیده
OBJECTIVE(S) Reflexes that rose from mechanoreceptors in nasal cavities have extensive neuro-regulatory effects on respiratory system. Because of side specific geometry and dual innervations of the nasal mucosa, we investigated the consequences of unilateral nasal stimulations on respiratory mechanics and breathing patterns. MATERIALS AND METHODS Unilateral nasal air-puff stimulation (30 min) in the presence of propranolol (25 mg/kg) and atropine (5 mg/kg) were applied on tracheotomized spontaneously breathing rats. Breathing rate and pattern monitored. Peak inspiratory pressure (PIP) and flow (PIF) were exploited for calculation of resistance, dynamic compliance (Cdyn), and estimation of respiratory system impedance (Zrs). RESULTS During right-side stimulation, in propranolol (P<0.05) and atropine groups (P<0.01) PIP significantly decreased in comparison to the control group. Alternatively, it significantly increased in left-side and propranolol-left groups (P<0.05) than control group. Mean Cdyn following left-side stimulation and propranolol, revealed significant decrements (P<0.05) than control group. In the case of atropine-right and atropine-left groups, mean Cdyn had significantly decreased in comparison with atropine alone (P<0.05). Airway resistance (R) did not reveal significant difference during nasal stimulations whereas least square approximation revealed a significant side-specific frequency dependent deviation of imaginary part of impedance (X). An inverse correlation was determined for Cdyn versus frequency following right side (R=-0.76) and left side (R=-0.53) stimulations. CONCLUSION For the reason that lower airways mechanics changed in a way independent from smooth muscle, it may be concluded from our data that unilateral nasal stimulations exert their different controls through higher regulatory centers.
منابع مشابه
Differential Consequences of Unilateral Nasal Air-Puff Stimulation on Breathing Pattern and Respiratory System Mechanics in Tracheotomized Rats
متن کامل
Detection of airway partitioning following unilateral nasal stimulations by the forced oscillation technique in rats.
Nasal mucosa has an extraordinary nerve supply with unique geometry that encompasses complex physiology. Among these, side-specific predilections to the respiratory and autonomic centers are the interesting issues that have been raised about the consequences of the nasal irritations. The aim of the study was an evaluation of how intranasal stimulation influences lung mechanics and determines wh...
متن کاملTiming of odor stimulation does not alter patterning of olfactory bulb unit activity in freely breathing rats.
1. The effect of the timing between nasal airflow and ongoing tracheal respiration on single-unit activity in the olfactory bulb (OB) of the rat was examined. Nasal and tracheal breathing were dissociated with the use of a double tracheal cannulation technique that allowed independent control of nasal airflow and control of the synchronization of nasal airflow and tracheal breathing. 2. When am...
متن کاملHY POXIA AND I TS INFLUEN CES ON THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS OF SPONTANEOUSLY BREATHING CATS
Effects of acute systemic hypoxia on the cardiovascular system (CYS) and respiration of spontaneously breathing cats were studied in two conditions. 1): Hypoxic air (6-8% 02 in N2) was given to the animal to induce systemic hypoxia for 20 minutes. Hyperventilation at this condition lowered arterial C02 tension (PaC02 hypocapnia). 2): In the second run, induction of hypocapnia was prevented ...
متن کاملThe Effects of Partial Turbinectomy on Patients Undergoing Rhinoplasty
Introduction: A reduction or cessation of the ability to breathe through the nose can affect a person's overall health. Nasal passage blockage can also result in snoring. Difficulty in breathing through the nose after rhinoplasty is a serious problem and patient dissatisfaction can be significant even when cosmetic results are excellent. Long-term impacts on the quality of life and contributio...
متن کامل